Evo-Devo (Despacito Biology Parody) | A Capella Science

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  • เผยแพร่เมื่อ:  วันเสาร์ที่ 23 กันยายน พ.ศ. 2560
  • This is how we go from single cells to people.
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    B. Mac.
    Oh Carroll, Carroll
    Gould, Stephen Jay yeah
    D-D-D-D-Davidson and Peter

    One cell divide and decide on a thousand fates
    Did you ever figure how they know?
    B. Mac.
    Are built of modules combined in a planned out way
    Each new piece must be told where to go

    Now there's a science helping us to understand
    How our cells encode this architectural plan
    Signalling each other with genetic tools oh
    Oh yeah

    Phenotype the interface for mouse and man
    Genotype the files and the subprograms
    What then are the switches, circuit boards and boot code?

    Looking at the logic in the ways that we grow
    Every gene directed by a signal key code
    Proteins that can activate, enhance or veto
    Signals are controlled by other genes that signal
    Calculating in a network labyrinthal
    Where the heart and liver and the hands and feet go

    Signal mapping tells each region what it ought to be yo
    With circuits so deeply built upon
    They're older than the Paleo
    The Paleozoic Era baby
    In a crucial pathway changes tend to get torpedoed
    Where they go calamity goes
    As this cyclopic sheep knows..

    See down they cascade like a domino
    Like you and I drosophila
    The path that makes us optical
    Was laid a long long time ago
    Back before we blew up the cambrian like a bomb bomb
    Now my eye protein can make you see out of your bom bom
    And Hedgehog and its relatives like Indian and Sonic
    Set up set up in a gradient on segments embryonic
    Split forebrains and asymmetric parts depend upon it
    Flipping on genetic switches and logic
    From devo to evo
    Adult and embryo
    Mostly don't evolve in the genes of the genome
    Safer the mutation aimed at regulation
    Keep the building blocks and swap their activation
    From devo to evo
    Parts have alter egos
    Homologs evolved from repeats in the schema
    Switch a couple bases in the proper places
    You'll be watching flies grow legs out of their faces oh yeah

    Stick around for Modern Synthesis the sequel
    Only by combining can a new theory grow
    Evolution and development amigos
    Signals trigger patterns of complexity so
    Switching up the switches of a signalling node
    Gives a modular and simple way to evolve

    Look at how our spinal segments generate a neat row
    Built on a molecular clock
    One cycle, one vertebra
    One vertebra one vertebra baby
    Speeding up its rate is snakes' developmental cheat code
    That and where a lizard's feet grow
    They turn off distal aminos

    This is how we go from single cells to people
    Every generation and in life primeval
    Life in variations endless and beautiful


    From devo to evo
    Larva to mosquito
    Patterns are resolved as the signals proceed yo
    Map out a gene with a glow tag
    Kill it with a morpholino
    Short oligo morpholino baby

    From devo to evo
    Voyage of the Beagle
    Body plans evolve when proteins steer the genome
    In this manner life's beauty grows
    Aesthetica in vivo

  • Source: https://youtu.be/ydqReeTV_vk